Damages to registry caused by registry cleaner:

The biggest disadvantage of Registry Cleaners is their weak distinction feature. Some Registry Cleaners fail to rate severity of errors and those succeeded erroneously categorized errors as critical without giving proper reason of categorization.

What are the disadvantages of Installing Registry Cleaners:

Critics question the validity of Registry Cleaners on the ground that there is no reliable method of assessing whether the third party application contains redundant information, invalid key or not.

Weakly developed registry cleaners may certainly not identify whether a particular key is still in use by Windows or what dire consequences it may have on being removed.

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The abovementioned flaw in Registry Cleaners create some worrisome situation such as malfunctioning of system, loss of functionality and accessing Microsofts application compatibility updates to prevent harmful Registry Cleaners.

Registry Cleaners fail to redeem scenarios like undeletable registry keys that occurred due to insertion of null characters in their names. However, there are few specialized tools available in the market, like RegDelNull utility and Sysinternals (now Microsoft), which could redeem such kinds of scenarios.

Potential to Recover:

Registry Cleaner could not repair those Registry hives which couldnt be mounted by the system.

However, there are several ways supported by Microsoft to repair a corrupt Registry. For example Automated System Recovery feature of Windows XP wherein last Known Good boot menu is achieved by using System Restore or by running setup.

Removal of Malware:

Despite all these problems, a corrupt registry can be recovered in several ways supported by Microsoft. For instance Automated System Recovery by using System Restore or by running setup from the Last Known Good boot menu.

Registry Cleaners fail to detect or delete Registry entries linked with a rootkit that can conceal this information from other processes.

A specialized tool is needed to compare the results of Registry APIs with the raw underlying Registry storage.

Do Registry Cleaners work in application virtualization scenario?

Registry cleaners fail to prove worthy in sanitizing registry entries related to virtualized applications as registry values in this case are written on a virtual registry that is application-specific in place of a real one.